The Holy Bible Verses

50 Bible Verses About Depression

Explore Bible verses about depression. Find comfort in scripture like Psalm 42:11 and discover hope and strength in God's presence.

By The Editorial Team

Verses sourced from the World English Bible (public domain). Selection follows our editorial policy. Last reviewed 2026-04-23. See all sources.

The Bible acknowledges the reality of depression, often depicting it as a deep emotional struggle. Psalm 42:11 encourages individuals to hope in God despite feelings of despair, emphasizing the importance of faith and trust in God's presence as a source of strength and comfort during difficult times.

“Why are you in despair, my soul? Why are you disturbed within me? Hope in God! For I shall still praise him, the saving help of my countenance, and my God.”
— Psalm 42:11 WEB

Dark moments often come when least expected. Feelings of depression can weigh heavily on the heart, making even the simplest task seem insurmountable. The Bible offers comfort through its verses, illustrating that feelings of despair are not foreign to the human experience. David, in 1 Samuel 30:6, faced great distress, yet he found strength in God. This shows that turning to faith can provide solace, even when surrounded by turmoil.

Job’s lament in Job 30:27 captures the essence of a troubled heart. His words resonate with those who feel overwhelmed by affliction. The Psalms, too, echo this sentiment. In Psalm 42:11, the psalmist asks, “Why are you cast down, O my soul?” and reminds us of the hope we can find in God. These verses offer a pathway through darkness, guiding us toward faith and hope. By acknowledging our struggles and seeking divine comfort, we can find peace.

50 verses

  1. 1

    “David was greatly distressed; for the people spoke of stoning him, because the souls of all the people were grieved, every man for his sons and for his daughters; but David strengthened himself in Yahweh his God.”

  2. 2

    “My heart is troubled, and doesn’t rest. Days of affliction have come on me.”

  3. 3

    “Many there are who say of my soul, “There is no help for him in God.”The Hebrew word rendered “God” is “אֱלֹהִ֑ים” (Elohim). Selah.”

  4. 4

    “My God, my God, why have you forsaken me? Why are you so far from helping me, and from the words of my groaning?”

  5. 5

    “Even though I walk through the valley of the shadow of death, I will fear no evil, for you are with me. Your rod and your staff, they comfort me.”

  6. 6

    “I will be glad and rejoice in your loving kindness, for you have seen my affliction. You have known my soul in adversities.”

  7. 7

    “Let me not be disappointed, Yahweh, for I have called on you. Let the wicked be disappointed. Let them be silent in Sheol.Sheol is the place of the dead.”

  8. 8

    “The righteous cry, and Yahweh hears, and delivers them out of all their troubles.”

  9. 9

    “Yahweh is near to those who have a broken heart, and saves those who have a crushed spirit.”

  10. 10

    “For innumerable evils have surrounded me. My iniquities have overtaken me, so that I am not able to look up. They are more than the hairs of my head. My heart has failed me.”

  11. 11

    “Why are you in despair, my soul? Why are you disturbed within me? Hope in God! For I shall still praise him for the saving help of his presence.”

  12. 12

    “My God, my soul is in despair within me. Therefore I remember you from the land of the Jordan, the heights of Hermon, from the hill Mizar.”

  13. 13

    “Why are you in despair, my soul? Why are you disturbed within me? Hope in God! For I shall still praise him, the saving help of my countenance, and my God.”

  14. 14

    “Why are you in despair, my soul? Why are you disturbed within me? Hope in God! For I shall still praise him: my Savior, my helper, and my God.”

  15. 15

    “God is our refuge and strength, a very present help in trouble.”

  16. 16

    “I am weary with my crying. My throat is dry. My eyes fail, looking for my God.”

  17. 17

    “In the day of my trouble I sought the Lord. My hand was stretched out in the night, and didn’t get tired. My soul refused to be comforted.”

  18. 18

    “I remember God, and I groan. I complain, and my spirit is overwhelmed. Selah.”

  19. 19

    “For my soul is full of troubles. My life draws near to Sheol.Sheol is the place of the dead.”

  20. 20

    “Some sat in darkness and in the shadow of death, being bound in affliction and iron,”

  21. 21

    “They mount up to the sky; they go down again to the depths. Their soul melts away because of trouble.”

  22. 22

    “Again, they are diminished and bowed down through oppression, trouble, and sorrow.”

  23. 23

    “My soul is weary with sorrow: strengthen me according to your word.”

  24. 26

    “Anxiety in a man’s heart weighs it down, but a kind word makes it glad.”

  25. 27

    “I applied my heart to seek and to search out by wisdom concerning all that is done under the sky. It is a heavy burden that GodThe Hebrew word rendered “God” is “אֱלֹהִ֑ים” (Elohim). has given to the sons of men to be afflicted with.”

  26. 28

    “and look to the earth, and see distress, darkness, and the gloom of anguish. They will be driven into thick darkness.”

  27. 29

    “Tell those who have a fearful heart, “Be strong. Don’t be afraid. Behold, your God will come with vengeance, God’s retribution. He will come and save you.”

  28. 30

    “For Yahweh has comforted Zion. He has comforted all her waste places, and has made her wilderness like Eden, and her desert like the garden of Yahweh. Joy and gladness will be found therein, thanksgiving, and the voice of melody.”

  29. 31

    “After the suffering of his soul, he will see the lightSo read the Dead Sea Scrolls and Septuagint. Masoretic Text omits “the light”. and be satisfied. My righteous servant will justify many by the knowledge of himself; and he will bear their iniquities.”

  30. 32

    “to provide for those who mourn in Zion, to give to them a garland for ashes, the oil of joy for mourning, the garment of praise for the spirit of heaviness; that they may be called trees of righteousness, the planting of Yahweh, that he may be glorified.”

  31. 33

    “In all their affliction he was afflicted, and the angel of his presence saved them. In his love and in his pity he redeemed them. He bore them, and carried them all the days of old.”

  32. 34

    “She who has borne seven languishes. She has given up the spirit. Her sun has gone down while it was yet day. She has been disappointed and confounded. I will deliver their residue to the sword before their enemies,” says Yahweh.”

  33. 35

    “For I have satiated the weary soul, and I have replenished every sorrowful soul.””

  34. 36

    “‘You said, “Woe is me now! For Yahweh has added sorrow to my pain! I am weary with my groaning, and I find no rest.”’”

  35. 37

    “All her people sigh. They seek bread. They have given their pleasant things for food to refresh their soul. “Look, Yahweh, and see; for I have become despised.””

  36. 38

    ““For these things I weep. My eye, my eye runs down with water, because the comforter who should refresh my soul is far from me. My children are desolate, because the enemy has prevailed.””

  37. 39

    ““Look, Yahweh; for I am in distress. My heart is troubled. My heart turns over within me, for I have grievously rebelled. Abroad, the sword bereaves. At home, it is like death.”

  38. 40

    “Don’t rejoice against me, my enemy. When I fall, I will arise. When I sit in darkness, Yahweh will be a light to me.”

  39. 41

    “the people who sat in darkness saw a great light, to those who sat in the region and shadow of death, to them light has dawned.”Isaiah 9:1-2”

  40. 42

    “Blessed are those who mourn, for they shall be comforted.Isaiah 61:2; 66:10,13”

  41. 43

    ““Come to me, all you who labor and are heavily burdened, and I will give you rest.”

  42. 44

    “About the ninth hour Jesus cried with a loud voice, saying, “Eli, Eli, limaTR reads “lama” instead of “lima” sabachthani?” That is, “My God, my God, why have you forsaken me?”Psalm 22:1”

  43. 45

    “I have told you these things, that in me you may have peace. In the world you have oppression; but cheer up! I have overcome the world.””

  44. 46

    “Let their eyes be darkened, that they may not see. Bow down their back always.”Psalm 69:22,23”

  45. 47

    “Now may the God of hope fill you with all joy and peace in believing, that you may abound in hope, in the power of the Holy Spirit.”

  46. 48

    “who comforts us in all our affliction, that we may be able to comfort those who are in any affliction, through the comfort with which we ourselves are comforted by God.”

  47. 49

    “Our hope for you is steadfast, knowing that, since you are partakers of the sufferings, so also are you of the comfort.”

  48. 50

    “Behold, we call them blessed who endured. You have heard of the perseverance of Job, and have seen the Lord in the outcome, and how the Lord is full of compassion and mercy.”

For your week

Reflect

Psalm 42:11 encourages us to hope in God despite our soul's turmoil. It reminds us that our feelings, while real, do not define our faith. We are invited to trust in God's unchanging nature.

Pray

Dear God, when waves of despair crash over me, help me find strength in You. Lift my spirit and fill my heart with hope. Guide me to Your peace and comfort. Amen.

Apply

This week, set aside five minutes each day to read Psalm 42:11 aloud. Reflect on its promise of hope and let it guide your thoughts toward peace.

Frequently Asked Questions

What does the Bible say about depression?

The Bible acknowledges the reality of depression and emotional distress. David's distress in 1 Samuel 30:6 and Job's afflicted heart in Job 30:27 show that even the faithful face such struggles. These examples encourage turning to God for strength and comfort, illustrating that faith is a refuge in times of emotional turmoil.

How do I find hope when depressed?

Hope in the midst of depression can be found by turning to Scripture and prayer. Psalm 42:11 invites us to put our hope in God, promising that He is our help and salvation. Regularly engaging with these verses and seeking God's presence in prayer can bring comfort and a renewed sense of hope.

Does God understand depression?

Yes, God understands depression. Jesus expressed deep sorrow on the cross, as seen in Psalm 22:1. This shows His empathy for human suffering. God offers comfort and understanding, encouraging those who are weary to seek refuge in His love and presence.

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